.png){kind=icon}
返回
Closed-Loop and Activity-Guided Optogenetic Control
.png){kind=icon}
OA
AI
DOI：10.1016/j.neuron.2015.03.034.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Advances in optical manipulation and observation of neural activity have set the stage for widespread implementation of closed-loop and activity-guided optical control of neural circuit dynamics. Closing the loop optogenetically (i.e., basing optogenetic stimulation on simultaneously observed dynamics in a principled way) is a powerful strategy for causal investigation of neural circuitry. In particular, observing and feeding back the effects of circuit interventions on physiologically relevant timescales is valuable for directly testing whether inferred models of dynamics, connectivity, and causation are accurate in vivo. Here we highlight technical and theoretical foundations as well as recent advances and opportunities in this area, and we review in detail the known caveats and limitations of optogenetic experimentation in the context of addressing these challenges with closed-loop optogenetic control in behaving animals.
Keyword:
SINGLE-CELL ELECTROPORATION
DEEP BRAIN-STIMULATION
IN-VIVO
NEURONAL-ACTIVITY
ACTION-POTENTIALS
LIGHT-FIELD
CIRCUIT DYNAMICS
GENE-EXPRESSION
OPTICAL CONTROL
NEURAL CIRCUIT
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
15
论文数:
1.4W
被引数:
9.9W
机构
引用论文
.png){kind=icon}
Corticotectal projections in the cat: Anterograde transport studies of twenty‐five cortical areas
PREAI
分享收藏
分享收藏
查看更多内容