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Closed- Loop Artificial Pancreas Systems: Engineering the Algorithms
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AI
DOI：10.2337/dc13-2108.png)
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摘要
En 中文
In this two-part Bench to Clinic narrative, recent advances in both the preclinical and clinical aspects of artificial pancreas (AP) development are described. In the preceding Bench narrative, Kudva and colleagues provide an in-depth understanding of the modified glucoregulatory physiology of type 1 diabetes that will help refine future AP algorithms. In the Clinic narrative presented here, we compare and evaluate AP technology to gain further momentum toward outpatient trials and eventual approval for widespread use. We enumerate the design objectives, variables, and challenges involved in AP development, concluding with a discussion of recent clinical advancements. Thanks to the effective integration of engineering and medicine, the dream of automated glucose regulation is nearing reality. Consistent and methodical presentation of results will accelerate this success, allowing head-to-head comparisons that will facilitate adoption of the AP as a standard therapy for type 1 diabetes.
Keyword:
INSULIN DELIVERY
GLUCOSE CONTROL
CLINICAL-EXPERIENCE
GLUCAGON DELIVERY
YOUNG-ADULTS
ADOLESCENTS
HYPOGLYCEMIA
FEASIBILITY
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
