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Clozapine treatment during the adolescent period reverses behavioral deficits in a dual-hit mouse model combining prenatal stress and maternal immune activation
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DOI：10.1016/j.pbb.2026.174179.png)
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Abstract
En 中文
• Combined prenatal stress and MIA produces comprehensive schizophrenia-like deficits in mice. • Dual-hit offspring show impaired PPI, social behavior, and increased immobility. • Clozapine treatment during the adolescent period fully reverses behavioral abnormalities. • Prefrontal Sptan1 downregulation and Glul upregulation identified in MODEL group. • Adolescent treatment window may prevent progression of neurodevelopmental pathology.
Keywords:
schizophrenia-like deficits
prenatal stress
maternal immune activation
clozapine
adolescent treatment
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