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Codonopsis pilosula (Dangshen) decoction promotes NR2F2-dependent pulmonary endothelial repair in an H9N2-induced lung injury model
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DOI：10.1016/j.jep.2026.122078.png)
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Abstract
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• Codonopsis pilosula decoction promoted pulmonary endothelial repair after H9N2 injury. • Dangshen decoction reduced lung edema, inflammation, and bronchoalveolar leakage in mice. • Dangshen decoction preserved endothelial continuity and junctional protein recovery in vivo. • C. pilosula restored NR2F2–NRP1–CCND1 signaling in injured lungs and MVECs. • NR2F2 was required for the pro-repair effects of C. pilosula in endothelial cells.
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