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Cofactor-Controlled Enantioselective Catalysis
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DOI：10.1021/ja208589c.png)
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摘要
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We report an achiral bisphosphine rhodium complex with a binding site for the recognition of chiral anion guests. Upon binding small chiral guests-cofactors-the rhodium complex becomes chiral and can thus be used for asymmetric catalysis. Screening of a library of cofactors revealed that the best cofactors lead to hydrogenation catalysts that form the products with high enantioselectivity (ee's up to 99%). Interestingly, a competition experiment shows that even in a mixture of 12 cofactors high ee is obtained, indicating that the complex based on the best cofactor dominates the catalysis.
Keyword:
SUPRAMOLECULAR CATALYSIS
SIGNAL AMPLIFICATION
BIDENTATE LIGANDS
HIGH-THROUGHPUT
TRANSITION
CHEMISTRY
MODELS
RECEPTORS
LIBRARIES
DESIGN
期刊
IF:
15.6
论文数:
20.0W
被引数:
60.2W
机构
引用论文
A combinatorial approach to the identification of self-assembled ligands for rhodium-catalysed asymmetric hydrogenation.png)
NATURE CHEMISTRY
NATURE CHEMISTRYIF20.2
PREAI
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