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Cofactor engineering powers next-generation biomanufacturing
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DOI：10.1016/j.tibtech.2026.03.010.png)
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Abstract
En 中文
Cofactor engineering can redistribute carbon fluxes from biomass accumulation toward the synthesis of high-value products, enabling sustainable production of pharmaceuticals and other fine chemicals with enhanced purity and yield. Light-driven and electrochemical cofactor regeneration can transform microbial platforms into autotrophic systems, potentially allowing the continuous bioproduction of chemicals from CO2 with a negative carbon footprint. Biocompatible materials can create robust microenvironments for cofactor recycling and enzyme preservation, potentially advancing the industrial-scale biomanufacturing of bulk chemicals such as biofuels and polymers. Integrated bioprocesses can leverage cofactor dynamics to achieve stable, large-scale production, overcoming metabolic bottlenecks in continuous-flow systems for green manufacturing.
Keywords:
Cofactor engineering
Biomanufacturing
Cofactor regeneration
Microbial platforms
Sustainable production
Journal
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14.9
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3.8K
Citations:
2.0W