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Combined agonism of nutrient receptors GPR40 and GPR119 with K-757 and K-833 results in weight loss and blood pressure reductions in obese subjects without type 2 diabetes mellitus
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DOI：10.1111/dom.70120.png)
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Abstract
En 中文
K-757 and K-833 are novel full agonists of GPR40 and GPR119, respectively, which are nutrient receptors co-expressed on both pancreatic beta cells and gut enteroendocrine cells that signal through complementary mechanisms. We sought to assess the effects beyond glucose control of co-agonism with K-757 and K-833.
Keywords:
antiobesity drug
clinical trial
obesity therapy
phases 1 and 2 study
randomised trial
weight management
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