Communicating with Hedgehogs

doi:10.1038/nrm1622

2005-04-01

790

PRE

Joan E. Hooper

Matthew P. Scott

DOI：10.1038/nrm1622

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摘要

En 中文

Signalling by secreted Hedgehog (Hh) proteins is important for the development of many tissues and organs. Damage to components of the Hh signal-transduction pathway can lead to birth defects and cancer. The Hh proteins are distributed in tissues in a gradient, and cells respond to different thresholds of Hh with distinct responses. The cellular machinery that is responsible for the unique molecular mechanisms of Hh signal transduction has been largely conserved during metazoan evolution.

Keyword:

KINESIN-RELATED PROTEIN

STEROL-SENSING DOMAIN

ZINC-FINGER PROTEIN

PICK C1 PROTEIN

SONIC-HEDGEHOG

SIGNAL-TRANSDUCTION

CUBITUS INTERRUPTUS

NEGATIVE REGULATOR

SUBCELLULAR-LOCALIZATION

DROSOPHILA ORTHOLOG

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期刊

Nature Reviews Molecular Cell Biology

IF:

90.2

论文数:

4.1K

被引数:

7.3W

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