Complement inhibition in C3 glomerulopathy

Carla Nester

doi:10.1016/j.smim.2016.06.002

2016-06-01

PRE

Carla Nester

Richard J. Smith *

DOI：10.1016/j.smim.2016.06.002

原文链接

摘要

En 中文

C3 glomerulopathy (C3G) describes a spectrum of glomerular diseases defined by shared renal biopsy pathology: a predominance of C3 deposition on immunofluorescence with electron microscopy permitting disease sub-classification. Complement dysregulation underlies the observed pathology, a causal relationship that is supported by well described studies of genetic and acquired drivers of disease. In this article, we provide an overview of the features of C3G, including a discussion of disease definition and a review of the causal role of complement. We discuss molecular markers of disease and how biomarkers are informing our evolving understanding of underlying pathology. Research advances are laying the foundation for complement inhibition as a targeted approach to treatment of C3G. (C) 2016 Elsevier Ltd. All rights reserved.

Keyword:

Membranoproliferative glomerulonephritis

C3 glomerulopathy

Complement

Dense deposit disease

C3 glomerulonephritis

Eculizumab

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期刊

Seminars in Immunology

IF:

7.8

论文数:

1.6K

被引数:

7.3K

机构

University of Iowa

学者数:

2.8W

论文数: 2.3W

被引数: 600

引用论文

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