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Complement Regulator Factor H in Multiple Sclerosis
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DOI：10.1002/jcb.23204.png)
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摘要
En 中文
A recent proteomic study published in this journal demonstrated lower cerebrospinal fluid (CSF) expression of factor H (fH), an important complement regulator, along with two other complement proteins, in active multiple sclerosis (MS) patients. We have previously demonstrated raised serum fH levels in MS and here, an extended analysis, quantifying fH in CSF, demonstrates no change in fH levels in active disease, but significantly raised levels in progressive disease. These findings support our previous work showing raised serum fH in patients with progressive MS, and our results predict that CSF fH levels will be raised rather than reduced in active disease. J. Cell. Biochem. 112: 2653-2654, 2011. (C) 2011 Wiley-Liss, Inc.
Keyword:
MULTIPLE SCLEROSIS
BIOMARKER
COMPLEMENT
FACTOR H
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期刊
IF:
2.8
论文数:
1.1W
被引数:
2.2W
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引用论文
Complement regulator factor H as a serum biomarker of multiple sclerosis disease state.png)
BRAINOAAI
BRAINIF11.7
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