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Complement regulators and inhibitory proteins
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DOI：10.1038/nri2620.png)
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The complement system is important for cellular integrity and tissue homeostasis. Complement activation mediates the removal of microorganisms and the clearance of modified self cells, such as apoptotic cells. Complement regulators control the spontaneously activated complement cascade and any disturbances in this delicate balance can result in damage to tissues and in autoimmune disease. Therefore, insights into the mechanisms of complement regulation are crucial for understanding disease pathology and for enabling the development of diagnostic tools and therapies for complement-associated diseases.
Keyword:
MEMBRANE COFACTOR PROTEIN
FACTOR-H
ALTERNATIVE PATHWAY
APOPTOTIC CELLS
PATTERN-RECOGNITION
CARBOXYPEPTIDASE-N
ENDOTHELIAL-CELLS
C5A ANAPHYLATOXIN
IMMUNE-RESPONSE
PROTECTIVE ROLE
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分享收藏分享收藏Structure of complement fragment C3b-factor H and implications for host protection by complement regulators.png)
NATURE IMMUNOLOGY
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NATURE IMMUNOLOGYIF27.6
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