COMPLEMENTing immunotherapy

Lubka T. Roumenina

doi:10.1038/s43018-022-00442-6

2022-10-21

PRE

Lubka T. Roumenina *

Isabelle Cremer

DOI：10.1038/s43018-022-00442-6

原文链接

摘要

En 中文

Intratumoral activation of the complement cascade may have therapeutic potential in patients with lung cancer with strong EGFR signaling, shows a new study. EGFR-triggered expression of CD55 and CD59 prevents opsonization of tumor cells, inhibits antitumor immunity and confers resistance to immune-checkpoint inhibitors.

Keyword:

LUNG-CANCER

ACTIVATION

BLOCKADE

期刊

Nature Cancer

IF:

28.5

论文数:

1.3K

被引数:

1.3W

机构

universite paris cite

学者数:

1.0K

论文数: 394

被引数: 7.8K

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