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Complex regression Doppler optical coherence tomography
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DOI：10.1117/1.JBO.23.4.046009.png)
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We introduce a new method to measure Doppler shifts more accurately and extend the dynamic range of Doppler optical coherence tomography (OCT). The two-point estimate of the conventional Doppler method is replaced with a regression that is applied to high-density B-scans in polar coordinates. We built a high-speed OCT system using a 1.68-MHz Fourier domain mode locked laser to acquire high-density B-scans (16,000 A-lines) at high enough frame rates (similar to 100 fps) to accurately capture the dynamics of the beating embryonic heart. Flow phantom experiments confirm that the complex regression lowers the minimum detectable velocity from 12.25 mm/s to 374 mu m/s, whereas the maximum velocity of 400 mm/s is measured without phase wrapping. Complex regression Doppler OCT also demonstrates higher accuracy and precision compared with the conventional method, particularly when signal-to-noise ratio is low. The extended dynamic range allows monitoring of blood flow over several stages of development in embryos without adjusting the imaging parameters. In addition, applying complex averaging recovers hidden features in structural images. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License.
Keyword:
optical coherence tomography
Doppler optical coherence tomography
high-speed optical coherence tomography
MHz Fourier domain mode locked laser
hemodynamics
期刊
IF:
2.9
论文数:
7.4K
被引数:
1.4W
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