.png){kind=icon}
返回
Complosome - the intracellular complement system
.png){kind=icon}
OA
AI
DOI：10.1038/s41581-023-00704-1.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Complement proteins and receptors with intracellular activity - the complosome - have emerged as important regulators of physiological processes. In this Review, the authors examine evidence of complosome activity across a variety of cells and tissues, as well as their contributions to human disease and therapeutic potential. The complement system is a recognized pillar of host defence against infection and noxious self-derived antigens. Complement is traditionally known as a serum-effective system, whereby the liver expresses and secretes most complement components, which participate in the detection of bloodborne pathogens and drive an inflammatory reaction to safely remove the microbial or antigenic threat. However, perturbations in normal complement function can cause severe disease and, for reasons that are currently not fully understood, the kidney is particularly vulnerable to dysregulated complement activity. Novel insights into complement biology have identified cell-autonomous and intracellularly active complement - the complosome - as an unexpected central orchestrator of normal cell physiology. For example, the complosome controls mitochondrial activity, glycolysis, oxidative phosphorylation, cell survival and gene regulation in innate and adaptive immune cells, and in non-immune cells, such as fibroblasts and endothelial and epithelial cells. These unanticipated complosome contributions to basic cell physiological pathways make it a novel and central player in the control of cell homeostasis and effector responses. This discovery, together with the realization that an increasing number of human diseases involve complement perturbations, has renewed interest in the complement system and its therapeutic targeting. Here, we summarize the current knowledge about the complosome across healthy cells and tissues, highlight contributions from dysregulated complosome activities to human disease and discuss potential therapeutic implications.
Keyword:
MEMBRANE COFACTOR PROTEIN
DECAY-ACCELERATING FACTOR
TOLL-LIKE RECEPTORS
ANAPHYLATOXIN RECEPTORS
COSTIMULATORY MOLECULE
CELL-DIFFERENTIATION
IFN-GAMMA
MEMORY B
T-CELLS
C3
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
N
IF:
39.8
论文数:
2.2K
被引数:
1.9W
机构
引用论文
Role of RadA and DNA Polymerases in Recombination-Associated DNA Synthesis in Hyperthermophilic Archaea.png)
BiomoleculesOAAI
BiomoleculesIF0
OAAI分享收藏Intracellular cytosolic complement component C3 regulates cytoprotective autophagy in pancreatic beta cells by interaction with ATG16L1胞内补体成分C3通过与ATG16L1相互作用调节胰腺 β 细胞的细胞保护性自噬AUTOPHAGYOAAI
AUTOPHAGYIF14.3
OAAI分享收藏LFA-1 in T cell priming, differentiation, and effector functionsT细胞启动、分化和效应子功能的LFA-1TRENDS IN IMMUNOLOGYOAAI
TRENDS IN IMMUNOLOGYIF13.9
OAAI分享收藏Intracellular complement C5a/C5aR1 stabilizes β-catenin to promote colorectal tumorigenesisCELL REPORTS
OAAI
CELL REPORTSIF6.9
OAAI分享收藏
查看更多内容