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Computational Approaches to Studying Thrombus Development
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DOI：10.1161/ATVBAHA.110.213397.png)
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In addition to descriptive biological models, many computational models have been developed for hemostasis/thrombosis that provide quantitative characterization of thrombus development. Simulations using computational models that have been developed for coagulation reactions, platelet activation, and fibrinogen assembly have been shown to be in close agreement with experimental data. Models of processes involved in hemostasis/thrombosis are being integrated to simulate the development of the thrombus simultaneously in time and space. Further development of computational approaches can provide quantitative insights leading to predictions that are not obvious from qualitative biological models. (Arterioscler Thromb Vasc Biol. 2011;31:500-505.)
Keyword:
blood coagulation
blood flow
coagulation
platelets
thrombosis
computational model
stochastic multiscale model
thrombus development
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7.4
论文数:
1.2W
被引数:
3.5W
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Blood flow velocity effects and role of activation delay time on growth and form of platelet thrombi
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