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Computer-based three-dimensional visualization of developmental gene expression
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DOI：10.1038/75989.png)
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摘要
En 中文
A broad understanding of the relationship between gene activation, pattern formation and morphogenesis will require adequate tools for three-dimensional and, perhaps four-dimensional, representation and analysis of molecular developmental processes. We present a novel, computer-based method for the 3D visualization of embryonic gene expression and morphological structures from serial sections. The information from these automatically aligned 3D reconstructions exceeds that from single-section and whole-mount visualizations of in situ hybridizations. In addition, these 3D models of gene-expression patterns can become a central component of a future developmental database designed for the collection and presentation of digitized, morphological and gene-expression data. This work is accompanied by a web site (http://www. univie.ac.at/GeneEMAC).
Keyword:
SERIAL SECTIONS
3D RECONSTRUCTION
3-DIMENSIONAL RECONSTRUCTION
MOUSE EMBRYOS
SYSTEM
SEGMENTATION
DERIVATIVES
DATABASE
DESIGN
MUTANT
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期刊
IF:
40
论文数:
1.0W
被引数:
10.5W
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THE NGF-INDUCIBLE SCG10 MESSENGER-RNA ENCODES A NOVEL MEMBRANE-BOUND PROTEIN PRESENT IN GROWTH CONES AND ABUNDANT IN DEVELOPING NEURONS.png)
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