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Conceptualizing microbe-plasmid communities as complex adaptive systems
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DOI：10.1016/j.tim.2023.01.007.png)
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摘要
En 中文
Plasmids shape microbial communities' diversity, structure, and function. Never-theless, we lack a mechanistic understanding of how community structure and dynamics emerge from local microbe-plasmid interactions and coevolution. Addressing this gap is challenging because multiple processes operate simulta-neously at multiple levels of organization. For example, immunity operates between a plasmid and a cell, but incompatibility mechanisms regulate coexistence between plasmids. Conceptualizing microbe-plasmid communities as complex adaptive systems is a promising approach to overcoming these challenges. I illustrate how agent-based evolutionary modeling, extended by network analysis, can be used to quantify the relative importance of local processes governing community dynam-ics. These theoretical developments can advance our understanding of plasmid ecology and evolution, especially when combined with empirical data.
Keyword:
LATERAL GENE-TRANSFER
ANTIBIOTIC-RESISTANCE
NETWORKS
MECHANISMS
STABILITY
EVOLUTION
DYNAMICS
MOBILITY
ECOLOGY
期刊
IF:
14.9
论文数:
3.9K
被引数:
1.9W
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引用论文
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