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Conformational and physicochemical properties of fucosylated chondroitin sulfate from sea cucumber Apostichopus japonicus
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DOI：10.1016/j.carbpol.2016.06.061.png)
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Abstract
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This study aimed at investigating the chain conformation and physicochemical properties of fucosylated chondroitin sulfate extracted from sea cucumber Apostichopus japonicas (Aj-fCS). By using HPSEC-MALLS-Visc-RI, M-w, (1/2)(z), R-h and [eta] for Aj-fCS were determined as 58.0 +/- 4.4 kDa, 21.8 +/- 1.3 nm, 12.5 +/- 1.3 nm and 27.8 +/- 0.5 mL/g respectively. Conformation parameter Lis derived from the relationship of M-w-(1/2)(z) (0.39) and structure -sensitive parameter rho (1.74) consistently indicated that Aj-fCS adopted a random coil conformation in solution, which was also supported by atomic force microscopy. Stiffness parameters of Aj-fCS chains including q (2.72 nm), d (1.03 nm) and C-infinity (5.28) were furthermore deduced from the worm-like cylinder model. Aj-fCS demonstrated a shear-thinning rheological behavior, relatively low apparent viscosity, negative charge in wide pH and ionic strength ranges, and favorable thermostability. These results have important implications for designing and fabricating functional foods or drugs based on Aj-fCS. (C) 2016 Elsevier Ltd. All rights reserved.
Keywords:
Sea cucumber
Fucosylated chondroitin sulfate
Chain conformation
zeta-Potential
Rheology
Thermostability
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