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Context-dependent androgen control of T cell immunity
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DOI：10.1016/j.it.2026.06.004.png)
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Abstract
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While androgen deprivation is widely used in urological oncology to restrain tumor growth and prevent T cell exhaustion, Lee et al. reveal a striking reversal in glioblastoma. In glioblastoma, androgen loss triggers microglial cytokines, activates the hypothalamic–pituitary–adrenal axis, and induces glucocorticoid-dependent T cell suppression, which accelerates tumor progression.
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