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Context-dependent epithelial and immune programs shape intestinal resilience or vulnerability following prior colitis
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DOI：10.1016/j.jcmgh.2026.101826.png)
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Abstract
En 中文
Prior intestinal inflammation can leave durable immune and epithelial alterations, yet how these changes influence responses to subsequent injury remains unclear. Infectious and sterile colitis share core features, including barrier disruption and cytokine secretion. We therefore investigated whether the nature of the initial inflammatory event shapes protection or susceptibility during later intestinal insult.
Keywords:
Citrobacter rodentium
DSS Colitis
mucosal immunity
epithelial barrier integrity
inflammatory memory
IL-17A
Enteropathogenic Escherichia coli
type III secretion system effectors
AIEC
Adherent-invasive Escherichia coli
AWERB
Animal Welfare and Ethical Review Body
BCA
Bicinchoninic acid
CCH
Colonic crypt hyperplasia
CFU
Colony forming units
CR
Citrobacter rodentium
DAI
Disease activity index
DAPI
4',6-diamidino-2-phenylindole
DSS
Dextran sodium sulphate
DTT
Dithiothreitol
ELISA
Enzyme-linked immunosorbent assay
FBS
Foetal bovine serum
FITC
Fluorescein isothiocyanate
FMO
Fluorescent-minus-one
H&E
Haematoxylin and eosin
HBSS
Hanks' balanced salt solution
HEPES
4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid
IBD
Inflammatory bowel disease
IEC
Intestinal epithelial cells
IFNγ
Interferon gamma
IL
Interleukin
ILC2
Group 2 innate lymphoid cells
ILC3
Group 3 innate lymphoid cells
LB
Lysogeny broth
LOD
Limit of detection
LOQ
Lower limit of quantification
MPO
Myeloperoxidase
NDS
Normal donkey serum
NE
Neutrophil elastase
PBS
Phosphate-buffered saline
PCNA
Proliferating cell nuclear antigen
PFA
Paraformaldehyde
qRT-PCR
Quantitative reverse transcription polymerase chain reaction
rIL-17A
Recombinant interleukin-17A
RIPA
Radioimmunoprecipitation assay
T3SS
Type III secretion system
Th1
T helper 1 cells
Th2
T helper 2 cells
Th17
T helper 17 cells
TNF
Tumour necrosis factor
Treg
Regulatory T cells
UT
Untreated
VC
Vehicle control
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