Contrasting Multi-Source Temporal Knowledge Graphs for Biomedical Hypothesis Generation

Huiwei Zhou

doi:10.1109/TCBB.2024.3451051

2024-11-01

PRE

DOI：10.1109/TCBB.2024.3451051

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摘要

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Hypothesis Generation (HG) aims to expedite biomedical researches by generating novel hypotheses from existing scientific literature. Most existing studies focused on modeling static snapshots of the corpus, neglecting the temporal evolution of scientific terms. Despite recent efforts to learn term evolution from Knowledge Bases (KBs) for HG, the temporal information from multi-source KBs is still overlooked, which contains important, up-to-date knowledge. In this paper, an innovative Temporal Contrastive Learning (TCL) framework is introduced to uncover latent associations between entities by jointly modeling their co-evolution across multi-source temporal KBs. Specifically, we first construct a temporal relation graph based on PubMed papers and a biomedical relation database (such as Comparative Toxicogenomics Database (CTD)). Then the constructed temporal relation graph and a temporal concept graph (such as Medical Subject Headings (MeSH)) are used to train two GCN-based recurrent networks for learning the entity temporal evolutional embeddings, respectively. Finally, a cross-view temporal prediction task is designed for learning knowledge enriched temporal embeddings by contrasting the temporal embeddings learned from the two Temporal Knowledge Graphs (TKGs). Findings from experiments conducted on three real-world biomedical term relationship datasets demonstrate that the proposed approach is clearly superior to approaches based on single TKG, achieving the state-of-the-art performance.

Keyword:

Contrastive learning

Evolution (biology)

Knowledge based systems

Hypertension

Computational modeling

Cardiovascular diseases

Biological system modeling

Hypothesis generation (HG)

temporal contrastive learning (TCL)

co-evolution

temporal knowledge graph (TKG)