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Controlled Bioactive Delivery Using Degradable Electroactive Polymers
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DOI：10.1021/acs.biomac.2c00516.png)
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Abstract
En 中文
Biomaterials capable of precisely controlling the delivery of agrochemicals/biologics/drugs/fragrances have significant markets in the agriscience/healthcare industries. Here, we report the development of degradable electroactive polymers and their application for the controlled delivery of a clinically relevant drug (the anti-inflammatory dexamethasone phosphate, DMP). Electroactive copolymers composed of blocks of polycaprolactone (PCL) and naturally occurring electroactive pyrrole oligomers (e.g., bilirubin, biliverdin, and hemin) were prepared and solution-processed to produce films (optionally doped with DMP). A combination of in silico/in vitro/in vivo studies demonstrated the cytocompatibility of the polymers. The release of DMP in response to the application of an electrical stimulus was observed to be enhanced by ca. 10-30% relative to the passive release from nonstimulated samples in vitro. Such stimuli-responsive biomaterials have the potential for integration devices capable of delivering a variety of molecules for technical/medical applications.
Keywords:
DRUG-DELIVERY
ENZYMATIC CONVERSION
RELEASE
HEME
PCL
BIOCOMPATIBILITY
DEXAMETHASONE
CHRONOBIOLOGY
PULMONARY
BILIRUBIN
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