Coordinated IFN-γ/TNF Axis Drives Selective Loss of Activated Enteric Glia in Inflammatory Bowel Diseases

Marvin Bubeck

doi:10.1016/j.jcmgh.2026.101827

Coordinated IFN-γ/TNF Axis Drives Selective Loss of Activated Enteric Glia in Inflammatory Bowel Diseases

2026-06-12

0

OA

AI

M

Marvin Bubeck

K

Klara A. Penkert

H

Heidi Limberger

M

Miguel González Acera

C

Christina Plattner

S

Svenja Ziegler

A

Anoohya Muppirala

P

Patrycja Forster

M

Manuel Jakob

R

Reyes Gamez-Belmonte

L

Lena Erkert

S

Subhash Kulkarni

C

Claudia Günther

R

Raja Atreya

A

Anja A. Kühl

A

Ahmed N. Hegazy

K

Kai Hildner

Z

Zlatko Trajanoski

B

Britta Siegmund

M

Markus F. Neurath

DOI：10.1016/j.jcmgh.2026.101827

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Abstract

En 中文

Enteric glial cells (EGCs) regulate gastrointestinal homeostasis and inflammation. While activated EGCs have been shown to support epithelial and immune balance in preclinical models, their functional status and turnover in inflammatory bowel diseases (IBD) remain poorly defined. This study aimed to identify EGC activation markers and assess their susceptibility to cytokine-driven death in IBD.

Keywords:

enteric glial cells

necroptosis

IFN-γ

TNF

inflammatory bowel disease

Coordinated IFN-γ/TNF Axis Drives Selective Loss of Activated Enteric Glia in Inflammatory Bowel Diseases

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