Copper regulates the synthesis of steroid hormones through CCS and ATOX1 dependent MEK1-ERK1/2 pathway in follicular granulosa cells of yak (Bos grunniens)

2026-05-02

PRE

Yanbing Lou

Tingting Yang

Chenglong Xia

Shijun Yang

Huidan Deng

Yanqiu Zhu

Jing Fang

Zhicai Zuo

Hongrui Guo *

DOI：10.1016/j.mce.2026.112812

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Abstract

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• CCS and ATOX1 is a specific target of copper in hormone secretion of ovarian granulosa cells. • MEK1-ERK1/2 pathway is involved in copper-affected hormone secretion. • Copper affects hormones secretion through CCS and ATOX1 dependent MEK1-ERK1/2 pathway.

Keywords:

Copper

CCS

ATOX1

MEK1-ERK1/2 pathway

Steroid hormones

Copper regulates the synthesis of steroid hormones through CCS and ATOX1 dependent MEK1-ERK1/2 pathway in follicular granulosa cells of yak (Bos grunniens)

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