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CREB Regulates Memory Allocation in the Insular Cortex
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DOI：10.1016/j.cub.2014.10.018.png)
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摘要
En 中文
The molecular and cellular mechanisms of memory storage have attracted a great deal of attention. By comparison, little is known about memory allocation, the process that determines which specific neurons in a neural network will store a given memory [1, 2]. Previous studies demonstrated that memory allocation is not random in the amygdala; these studies showed that amygdala neurons with higher levels of the cyclic-AMP-response-element-binding protein (CREB) are more likely to be recruited into encoding and storing fear memory [3-6]. To determine whether specific mechanisms also regulate memory allocation in other brain regions and whether CREB also has a role in this process, we studied insular cortical memory representations for conditioned taste aversion (CTA). In this task, an animal learns to associate a taste (conditioned stimulus [CS]) with the experience of malaise (such as that induced by Lid; unconditioned stimulus [US]). The insular cortex is required for CIA memory formation and retrieval [7-12]. CTA learning activates a subpopulation of neurons in this structure [13-15], and the insular cortex and the basolateral amygdala (BLA) interact during CTA formation [16, 17]. Here, we used a combination of approaches, including viral vector transfections of insular cortex, arc fluorescence in situ hybridization (FISH), and designer receptors exclusively activated by designer drugs (DREADD) system, to show that CREB levels determine which insular cortical neurons go on to encode a given conditioned taste memory.
Keyword:
CONDITIONED TASTE-AVERSION
LONG-TERM POTENTIATION
GUSTATORY CORTEX
INHIBITION
AMYGDALA
EXPRESSION
CONSOLIDATION
ACTIVATION
INDUCTION
REVEALS
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7.5
论文数:
2.2W
被引数:
7.8W
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