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Current developments in LC-MS for pharmaceutical analysis
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DOI：10.1039/c9an02145k.png)
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摘要
En 中文
The current developments in liquid chromatography-mass spectrometry (LC-MS) and its applications to the analysis of pharmaceuticals are reviewed. Various mass spectrometric techniques, including electrospray and nanospray ionization, atmospheric pressure chemical ionization and photoionization and their interface with liquid chromatographic techniques are described. These include high performance liquid chromatography, capillary electrophoresis and capillary electrochromatography and the advantages and disadvantages of each technique are discussed. The applications of LC-MS to the studies of in vitro and in vivo drug metabolism, identification and characterization of impurities in pharmaceuticals, analysis of chiral impurities in drug substances and high-throughput LC-MS-MS systems for applications in the accelerated drug discovery process are described.
Keyword:
2-DIMENSIONAL LIQUID-CHROMATOGRAPHY
TANDEM MASS-SPECTROMETRY
ATMOSPHERIC-PRESSURE PHOTOIONIZATION
UHPLC-MS/MS METHOD
HUMAN PLASMA
RAT PLASMA
ELECTROSPRAY-IONIZATION
PERFORMANCE
RESOLUTION
QUANTIFICATION
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期刊
A
IF:
3.3
论文数:
1.6W
被引数:
3.3W
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