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Current insights into the formation and breakdown of hemidesmosomes
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DOI：10.1016/j.tcb.2006.05.004.png)
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Abstract
En 中文
Hemidesmosomes are multiprotein adhesion complexes that promote epithelial stromal attachment in stratified and complex epithelia. Modulation of their function is of crucial importance in a variety of biological processes, such as differentiation and migration of keratinocytes during wound healing and carcinoma invasion, in which cells become detached from the substrate and acquire a motile phenotype. Although much is known about the signaling potential of the alpha 6 beta 4 integrin in carcinoma cells, the events that coordinate the disassembly of hemidesmosomes during differentiation and wound healing remain unclear. The binding of alpha 6 beta 4 to plectin has a central role in hemidesmosome assembly and it is becoming clear that disrupting this interaction is a crucial event in hemidesmosome disassembly. In addition, further insight into the functional interplay between alpha 3 beta 1 and alpha 6 beta 4 has contributed to our understanding of hemidesmosome disassembly and cell migration.
Keywords:
INTEGRIN BETA-4 SUBUNIT
ACTIN-BINDING DOMAIN
MACROPHAGE-STIMULATING PROTEIN
EPITHELIAL-CELL MIGRATION
ALPHA-6-BETA-4 INTEGRIN
EPIDERMOLYSIS-BULLOSA
BASEMENT-MEMBRANE
ALPHA-3-BETA-1 INTEGRIN
KERATINOCYTE MIGRATION
CYTOPLASMIC DOMAIN
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