Cutaneous T-cell lymphomas

doi:10.1016/j.bulcan.2024.07.012

2025-09-01

PRE

M. D’Incan *

DOI：10.1016/j.bulcan.2024.07.012

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原始皮肤T细胞淋巴瘤是指临床诊断时仅限于皮肤的淋巴瘤，与系统性淋巴瘤的皮肤局部病变相对。皮肤T细胞淋巴瘤是最常见的类型。除真菌样霉菌病及相关形式外，CD30+淋巴增殖性疾病（淋巴瘤样丘疹病、间变性大细胞原始皮肤T细胞淋巴瘤）和红皮病性T细胞淋巴瘤构成了主要实体，其他罕见的淋巴瘤有：类脂膜炎样α/β淋巴瘤、γ/δ淋巴瘤、亲表皮性CD8+侵袭性淋巴瘤、小到中等大小T细胞淋巴瘤以及肢端CD8+淋巴增殖性疾病。临床皮肤检查和皮肤活检检查对诊断至关重要，但分子遗传学领域的最新进展为诊断提供了有前景的工具。得益于国际协作组，真菌样霉菌病、CD30+淋巴增殖性疾病和红皮病性淋巴瘤的治疗现已得到充分确立，而其他实体的治疗则不然。治疗方法可分为五类：皮肤导向疗法、系统性非化疗疗法、免疫调节剂、靶向免疫疗法和化疗。

Keyword:

Cutaneous T-cell lymphomas

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Bulletin du Cancer

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