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CX3CR1+ synovial macrophages accumulate in the joint during experimental hemophilic arthropathy but are not required for acute synovitis

delete2026-05-12
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OA
AI
A
Alexander G. Lawrence
T
Tatenda Murangi
A
Anne Chevalier
D
Daniel Ivers
J
James S. O'Donnell
P
Peter L. Turecek
P
Padraic G. Fallon *
DOI:10.1016/j.jtha.2026.04.035delete
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Abstract

Abstract

En 中文
Hemophilic arthropathy (HA) is a chronic joint disease caused by repeated joint bleeding in patients with hemophilia (PWH), leading to joint degeneration despite prophylactic treatment. The CX3CL1(fractalkine)-CX3CR1 chemokine axis regulates synovial lining macrophage function and has been implicated in inflammatory joint diseases including rheumatoid arthritis and osteoarthritis.
Keywords:
Hemophilia A
Hemophilic arthropathy
Inflammation
CX3CR1
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Journal

Journal of Thrombosis and Haemostasis cover
Journal of Thrombosis and Haemostasis
IF:
5
Papers:
9.8K
Citations:
2.3W

Organization

U
university of vienna
Scholars:
2.4K
Papers: 1.2K
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T
Trinity College Dublin
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R
royal college of surgeons in ireland
Scholars:
465
Papers: 217
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