返回
Cyclodextrin-based pharmaceutics: Past, present and future
DOI:10.1038/nrd1576.png)
摘要
En 中文
Cyclodextrins are cyclic oligomers of glucose that can form water-soluble inclusion complexes with small molecules and portions of large compounds. These biocompatible, cyclic oligosaccharides do not elicit immune responses and have low toxicities in animals and humans. Cyclodextrins are used in pharmaceutical applications for numerous purposes, including improving the bioavailability of drugs. Current cyclodextrin-based therapeutics are described and possible future applications discussed. Cyclodextrin-containing polymers are reviewed and their use in drug delivery presented. Of specific interest is the use of cyclodextrin-containing polymers to provide unique capabilities for the delivery of nucleic acids.
Keyword:
PIROXICAM-BETA-CYCLODEXTRIN
CARBOHYDRATE-CONTAINING POLYCATIONS
INTRACAVERNOUS ALPROSTADIL ALFADEX
AMORPHOUS DRUG DISPERSIONS
OP-1206 ALPHA-CD
GENE DELIVERY
IN-VITRO
CONTAINING POLYMERS
BIODEGRADABLE/BIOABSORBABLE POLYMERS
POLYAMIDOAMINE DENDRIMER
AI总结
对已上传原文的论文进行重点信息的提取,主要内容包括:简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
101.8
论文数:
5.1K
被引数:
5.3W
机构
暂无机构信息
引用论文
Clinical evaluation, dose-finding and acceptability of AERODIOL®, the pulsed estrogen therapy for treatment of climacteric symptoms
MATURITAS
IF3.6
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings在药物发现和开发环境中估算溶解度和渗透性的实验和计算方法
A novel polymeric chlorhexidine delivery device for the treatment of periodontal disease
BIOMATERIALS
IF12.9

