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Cyclodextrin-based pharmaceutics: Past, present and future

delete2004-12-01
delete1.9K
PRE
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M
Mark E. Davis
M
Marcus E. Brewster
DOI:10.1038/nrd1576delete
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摘要

摘要

En 中文
Cyclodextrins are cyclic oligomers of glucose that can form water-soluble inclusion complexes with small molecules and portions of large compounds. These biocompatible, cyclic oligosaccharides do not elicit immune responses and have low toxicities in animals and humans. Cyclodextrins are used in pharmaceutical applications for numerous purposes, including improving the bioavailability of drugs. Current cyclodextrin-based therapeutics are described and possible future applications discussed. Cyclodextrin-containing polymers are reviewed and their use in drug delivery presented. Of specific interest is the use of cyclodextrin-containing polymers to provide unique capabilities for the delivery of nucleic acids.
Keyword:
PIROXICAM-BETA-CYCLODEXTRIN
CARBOHYDRATE-CONTAINING POLYCATIONS
INTRACAVERNOUS ALPROSTADIL ALFADEX
AMORPHOUS DRUG DISPERSIONS
OP-1206 ALPHA-CD
GENE DELIVERY
IN-VITRO
CONTAINING POLYMERS
BIODEGRADABLE/BIOABSORBABLE POLYMERS
POLYAMIDOAMINE DENDRIMER
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期刊

Nature Reviews Drug Discovery 封面图
Nature Reviews Drug Discovery
IF:
101.8
论文数:
5.1K
被引数:
5.3W

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