返回
Cytochrome c assembly
DOI:10.1002/iub.1123.png)
摘要
En 中文
Cytochromes c are central proteins in energy transduction processes by virtue of their functions in electron transfer in respiration and photosynthesis. They have heme covalently attached to a characteristic CXXCH motif via protein-catalyzed post-translational modification reactions. Several systems with diverse constituent proteins have been identified in different organisms and are required to perform the heme attachment and associated functions. The necessary steps are translocation of the apocytochrome polypeptide to the site of heme attachment, transport and provision of heme to the appropriate compartment, reduction and chaperoning of the apocytochrome, and finally, formation of the thioether bonds between heme and two cysteines in the cytochrome. Here we summarize the established classical models for these processes and present recent progress in our understanding of the individual steps within the different cytochrome c biogenesis systems. (c) 2013 IUBMB Life, 65(3):209216, 2013
Keyword:
cytochrome c
cytochrome c maturation
Ccm
heme
post-translational modification
holocytochrome c synthase
HCCS
期刊
IF:
3.2
论文数:
3.1K
被引数:
7.6K
机构
引用论文
Maturation of the unusual single-cysteine (XXXCH) mitochondrial c-type cytochromes found in trypanosomatids must occur through a novel biogenesis pathway在锥虫中发现的异常单半胱氨酸 (XXXCH) 线粒体c型细胞色素的成熟必须通过一种新的生物发生途径发生
BIOCHEMICAL JOURNAL
IF4.3
Order within a mosaic distribution of mitochondrial c-type cytochrome biogenesis systems?线粒体c型细胞色素生物发生系统的镶嵌分布中的顺序?
FEBS JOURNAL
IF4.2

