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Datamonkey 3: browser-native molecular evolution analysis

delete2026-09-09
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OA
AI
S
Steven Weaver
B
BM Ben Murrell
A
AN Anton Nekrutenko
S
Sergei L. Kosakovsky Pond *
DOI:10.3389/fbinf.2026.1876305delete
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摘要

摘要

En 中文
我们介绍了Datamonkey 3,它是分子进化分析Web平台Datamonkey的浏览器原生实现。通过利用WebAssembly在客户端执行HyPhy分析引擎,Datamonkey 3消除了标准分析对远程计算集群的依赖。该架构通过本地处理序列确保数据主权,并实现具有即时反馈的交互式工作流程。该平台提供一套全面的统计方法用于检测自然选择和重组,并由一个能够识别和纠正常见格式错误的数据整理系统支持。此外,Datamonkey 3集成了数据驱动的运行时估计和交互式结果可视化。通过将计算负担转移到客户端,Datamonkey 3建立了一种可持续的、保护隐私的基础设施模型,该模型可随用户基础扩展,证明了客户端基因组推断的可行性。虽然该浏览器原生架构专为选择和重组的进化分析而设计,但它为部署无服务器依赖的复杂生物信息学工具提供了一个可推广的蓝图。Datamonkey 3可免费访问https://v3.datamonkey.org,所有源代码可从https://github.com/veg/datamonkey3获取。
Keyword:
phylogenetics,molecular evolution,HyPhy,selection detection,WebAssembly

期刊

Frontiers in Bioinformatics 封面图
Frontiers in Bioinformatics
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3.9
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482
被引数:
1.1K

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department of biochemistry and molecular biology
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359
论文数: 157
被引数: 16
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Department of Microbiology
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institute for genomics and evolutionary medicine
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11
论文数: 3
被引数: 0
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引用论文

引用论文

Less Is More: An Adaptive Branch-Site Random Effects Model for Efficient Detection of Episodic Diversifying Selection
err2015-02-19
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errSmith, Martin D.; Wertheim, Joel O.; Weaver, Steven; Murrell, Ben; Scheffler, Konrad; Pond, Sergei L. Kosakovsky
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Spidermonkey: rapid detection of co-evolving sites using Bayesian graphical models
err2008-06-18
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errArt F. Y. Poon; Fraser I. Lewis; Simon D. W. Frost; Sergei L. Kosakovsky Pond
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Extra base hits: Widespread empirical support for instantaneous multiple-nucleotide changes
err2021-03-12
err0
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errAlexander G. Lucaci; Sadie R. Wisotsky; Stephen D. Shank; Steven Weaver; Sergei L. Kosakovsky Pond
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Selecton 2007: advanced models for detecting positive and purifying selection using a Bayesian inference approach
err2007-05-08
err304
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errStern, Adi; Doron-Faigenboim, Adi; Erez, Elana; Martz, Eric; Bacharach, Eran; Pupko, Tal
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Detecting Individual Sites Subject to Episodic Diversifying Selection
err2012-07-12
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errMurrell, Ben; Wertheim, Joel O.; Moola, Sasha; Weighill, Thomas; Scheffler, Konrad; Pond, Sergei L. Kosakovsky
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Characterizing Physicochemical Selection in Protein Evolution with Property-Informed Models (PRIME)
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IF0
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err0
PREAI
errKim,Hannah; Scheffler,Konrad; Nekrutenko,Anton; Martin,Darren P.; Weaver,Steven; Murrell,Ben; Kosakovsky Pond,Sergei L.
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Datamonkey 2.0: A Modern Web Application for Characterizing Selective and Other Evolutionary Processes
err2018-01-02
err619
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errWeaver, Steven; Shank, Stephen D.; Spielman, Stephanie J.; Li, Michael; Muse, Spencer V.; Pond, Sergei L. Kosakovsky
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