返回
Declining prevalence and increasing awareness of HCV infection in Italy: A population-based survey in five metropolitan areas
10.1016/j.ejim.2018.02.015
2018-07-01
78
PRE
AI
摘要
En 中文
Background: Data on the prevalence of hepatitis C virus (HCV) infection in Italy are outdated and usually derived from studying residents in small towns. Methods: To assess prevalence of and risk factors for HCV infection among Italian residents in 5 metropolitan areas, subjects >= 20 years of age were randomly selected from the list of the general practitioners' registers in 2015. Anti-HCV was tested by a salivary test; HCV-RNA, HCV genotypes, and ALT were determined in positive individuals. Logistic regression analysis evaluated independent risk factors for HCV. Results: Of the 4907 enrolled subjects, 112 (2.3%) tested anti-HCV positive. The prevalence of HCV increased with age, from 0.2% in subjects born after the year 1984, to 4.2% in those born before the year 1935 (P < 0.01). The birth-cohort prevalence peaked (7.0%) in elderly. Serum HCV-RNA was detected in 1.7% of the whole population. Nearly 80% of anti-HCV subjects were aware of their status. Age > 70 years, low education level, past use of glass syringes, blood transfusion, intravenous drug use, and cohabitation with an anti-HCV positive subject predicted the HCV positivity. Interpretation: In metropolitan areas in Italy, HCV is prevalent in elderly, reflecting a cohort effect determined by modalities of viral transmission no longer operative. The impact of the infection will further diminish in the years to come due to the natural depletion of the reservoir of the virus. This age pattern and the high proportion of subjects aware of their status do not warrant a policy of screening.
关键词:
HCV
HCV infection
Epidemiology
Risk factors
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
6.1
论文数: 5.6K
・
被引数: 8.6K
学者
A
Andriulli, Angelo
H 指数:
0
论文数: 10
・
被引数: 0
S
Stroffolini, Tommaso
H 指数:
0
论文数: 39
・
被引数: 0
M
Mariano, Andrea
H 指数:
0
论文数: 1
・
被引数: 0
V
Valvano, Maria Rosa
H 指数:
0
论文数: 4
・
被引数: 0
G
Grattagliano, Ignazio
H 指数:
0
论文数: 1
・
被引数: 0
查看更多内容机构
I
irccs casa sollievo della sofferenza
学者数:
2.5K
论文数: 2.0K
・
被引数: 1
I
irccs lazzaro spallanzani
学者数:
2.3K
论文数: 1.4K
・
被引数: 1
U
university hospital sapienza rome
学者数:
3.2K
论文数: 2.1K
・
被引数: 0
U
University of Turin
学者数:
3.7W
论文数: 2.8W
・
被引数: 3.2W
S
sapienza university rome
学者数:
6.1W
论文数: 4.6W
・
被引数: 353
U
universita della campania vanvitelli
学者数:
1.8W
论文数: 1.3W
・
被引数: 6
引用论文