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Decoding complex patterns of oncogene amplification
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DOI：10.1038/s41588-021-00974-0.png)
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Abstract
En 中文
Oncogene amplification is a major driver of tumorigenesis; yet, the mechanisms generating amplification are only partially understood. New research reports on the identification of a new focal amplification pattern termed 'seismic amplification' that is hypothesized to originate from recombination between extrachromosomal DNA circles.
Keywords:
GENOMIC REARRANGEMENT
CANCER
CHROMOTHRIPSIS
MECHANISMS
EVOLUTION
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