Decoding schizophrenia through postmortem human brain transcriptomics

W. Brad Ruzicka

doi:10.1016/j.gde.2026.102434

2026-02-01

PRE

W. Brad Ruzicka *

Sivan Subburaju

DOI：10.1016/j.gde.2026.102434

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摘要

En 中文

精神分裂症是一种高度可遗传的神经精神障碍，影响约1%的人口，但由于缺乏明显的神经病理学变化，其病理生理机制一直不明确。近年来，对死后人类脑组织转录组学分析的进展开始揭示该疾病的分子结构。这篇小型综述综合了病例对照组织块和单核转录组学研究的结果，揭示精神分裂症的特征是前额叶皮层中兴奋性神经元内广泛但细微的基因表达变化。突触和代谢基因的下调是一个持续出现的主题，伴随着胶质细胞群的继发性激活。单细胞分辨率研究显示，这些转录改变具有细胞类型特异性和个体间异质性，上层兴奋性神经元表现出特别的易损性。尽管存在与死后组织分析相关的方法学挑战，多个大规模联盟的汇聚证据确立了转录失调是精神分裂症病理生理学的核心特征。未来方向包括扩展队列和额外脑区，以及空间转录组学和异构体水平分析，以全面绘制这种复杂疾病的分子景观。

Keyword:

GENE-EXPRESSION

PREFRONTAL CORTEX

DEFICITS

NEURONS

RISK

DISORDER

期刊

CURRENT OPINION IN GENETICS & DEVELOPMENT

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3.6

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harvard university medical affiliates

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5.8W

论文数: 4.5W

被引数: 1.4W

Harvard University

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5.7K

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