.png){kind=icon}
返回
Decrease in Ins+Glut2LO β-cells with advancing age in mouse and human pancreas
.png){kind=icon}
OA
AI
DOI：10.1530/JOE-16-0475.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
The presence and location of resident pancreatic beta-cell progenitors is controversial. A subpopulation of insulin-expressing but glucose transporter-2-low (Ins(+)Glut2(LO)) cells may represent multipotent pancreatic progenitors in adult mouse and in human islets, and they are enriched in small, extra-islet beta-cell clusters (< 5 beta cells) in mice. Here, we sought to identify and compare the ontogeny of these cells in mouse and human pancreata throughout life. Mouse pancreata were collected at postnatal days 7, 14, 21, 28, and at 3, 6, 12, and 18 months of age, and in the first 28 days after beta-cell mass depletion following streptozotocin (STZ) administration. Samples of human pancreas were examined during fetal life (22-30 weeks gestation), infancy (0-1 year), childhood (2-9), adolescence (10-17), and adulthood (18-80). Tissues were analyzed by immunohistochemistry for the expression and location of insulin, GLUT2 and Ki67. The proportion of beta cells within clusters relative to that in islets was higher in pancreas of human than of mouse at all ages examined, and decreased significantly at adolescence. In mice, the total number of Ins(+)Glut2(LO) cells decreased after 7 days concurrent with the proportion of clusters. These cells were more abundant in clusters than in islets in both species. A positive association existed between the appearance of new beta cells after the STZ treatment of young mice, particularly in clusters and smaller islets, and an increased proportional presence of Ins(+)Glut2(LO) cells during early beta-cell regeneration. These data suggest that Ins(+)Glut2(LO) cells are preferentially located within beta-cell clusters throughout life in pancreas of mouse and human, and may represent a source of beta-cell plasticity.
Keyword:
aging
beta-cell
Glut2
islet
regeneration
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
3.9
论文数:
5.2K
被引数:
1.1W
机构
引用论文
Lineage tracing and resulting phenotype of haemopoietic-derived cells in the pancreas during beta cell regeneration.png)
DIABETOLOGIA
OAAI
DIABETOLOGIAIF10.2
OAAI分享收藏Pancreatic Exocrine Duct Cells Give Rise to Insulin-Producing β Cells during Embryogenesis but Not after Birth胰腺外分泌管细胞在胚胎发生过程中产生产生胰岛素的 β 细胞，但在出生后却没有DEVELOPMENTAL CELLOAAI
DEVELOPMENTAL CELLIF8.7
OAAI分享收藏Precursor Cells in Mouse Islets Generate New β-Cells in Vivo during Aging and after Islet InjuryENDOCRINOLOGYOAAI
ENDOCRINOLOGYIF3.3
OAAI分享收藏The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulationDIABETOLOGIAOAAI
DIABETOLOGIAIF10.2
OAAI分享收藏Age Before Stage: Insulin Resistance Rises Before the Onset of Puberty A 9-year longitudinal study (Early Bird 26)DIABETES CAREOAAI
DIABETES CAREIF16.6
OAAI分享收藏Growth and regeneration of adult β cells does not involve specialized progenitorsDEVELOPMENTAL CELLOAAI
DEVELOPMENTAL CELLIF8.7
OAAI分享收藏
查看更多内容