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Decrease in Longitudinal Wave Velocity in Glycated Collagen
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DOI：10.1109/TUFFC.2021.3078800.png)
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Diabetic patients have a higher risk of bone fracture than those without diabetes, despite a normal bone mineral density. This higher risk may result from the deterioration of collagen because of glycation. The objective of this study was to investigate the elastic properties of glycated collagen using the micro-Brillouin scattering technique. Using single-layer uniaxial collagen films with a thickness of approximately 30 mu m, the longitudinal wave velocities, propagating in the parallel and perpendicular directions with respect to the collagen fiber orientation, were measured in dry and wet film specimens. The wave velocities in the glycated collagen specimens decreased as a function of glycation time. This decrease depended on the direction of collagen fiber alignment and wave propagation. The lowest velocity due to glycation in the wet films was found when the ultrasound propagated perpendicular to the fiber direction. These results indicate that the glycation of collagen in the bone may also reduce bone elasticity and suggest that the effects of glycation on collagen films may be anisotropic.
Keyword:
Advanced glycation end products (AGEs)
collagen film
longitudinal wave velocity
micro-Brillouin scattering
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