DELs Inside Cells

doi:10.1016/j.tips.2020.01.007

2020-04-01

PRE

Animesh Roy

Thomas Kodadek *

DOI：10.1016/j.tips.2020.01.007

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摘要

En 中文

DNA-encoded libraries (DELs) comprise large numbers of small molecules, each of which is conjugated to an encoding DNA. Krusemark and colleagues recently described a method to introduce DELs into living cells and recover conjugates that bind to an intracellular target. This proof-of-principle study suggests that it may be feasible to screen DELs against protein targets in their native environment.

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Trends in Pharmacological Sciences

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University of Florida

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State University System of Florida

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被引数: 130

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