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Deprescribing of blood pressure-lowering medications in patients with hypotensive syncope
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DOI：10.1016/j.ejim.2026.107119.png)
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Abstract
En 中文
• We assessed the efficacy of deprescribing blood pressure–lowering medications in hypertensive patients suffering from severe hypotensive syncope. • In a cohort of 92 patients the total number of hypotensive medications decreased from 2.4 ± 1.1 per patient before deprescribing to 1.3 ± 1.0 per patient after the intervention. • The 24-hour systolic blood pressure increased from 118.8 ± 10.8 mmHg at ABPM 1 to 127.5 ± 11.6 at ABPM 2 (p = 0.0001). • The number of daytime SBP drops <90 mmHg and <100 mmHg decreased by 52% and 53% respectively (p = 0.0001 for both). • During the mean follow-up of 12.6 ± 3.8 months, the syncope burden dropped by 66% (p = 0.0001).
Keywords:
Reflex syncope
24-hour ambulatory blood pressure monitoring
Antihypertensive drugs
Orthostic hypotension
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