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Depression: Cognition relations after stroke
DOI:10.1111/ijs.12057.png)
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BackgroundPoststroke depression and cognitive dysfunction are common and are independent predictors of poor recovery. AimsWe assessed whether and how depression and cognition were correlated in the subacute period after stroke. MethodWe prospectively recruited 207 nondemented patients (Mini Mental State Examination23) presenting with a first-ever ischemic stroke (127 males), mean age of 485 years (164 standard deviation), median 12 days after infarction, as assessed on magnetic resonance imaging. We administered a comprehensive neuropsychological battery involving cognitive domains including instrumental functions, memory, executive functions, and working memory. Depression was quantified with the Beck Depression Inventory. ResultsDepression (Beck Depression Inventory>9) was identified in 304% of the patients (95% confidence interval 242-372%). Median Beck Depression Inventory was 6. Median Mini Mental State Examination was 30. Cognitive dysfunctioning in at least one neuropsychological test was present in 89% (95% confidence interval 84-93%). Each point increase of Beck Depression Inventory was associated with an odd of 11 (95% confidence interval 104-119) of changing to a worse category of cognition. Stroke location was not correlated with depression. All cognitive domains were significantly correlated with depression. In multivariate analysis, the executive functions (P=0001) and the working memory (P=0009) were the best predictors of depression when adjusted for demographic and stroke characteristics. ConclusionsThe rates of depression and cognitive impairment were in the range of previous stroke studies. Our study suggested a strong relation between depression and cognition characterized by executive functions and working memory dysfunctioning.
Keyword:
brain
ischemic stroke
lesions
neurology
rehabilitation
stroke subtypes
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