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Depression vulnerability involves brain activity and connectivity changes consistent with cholinergic deviancy

delete2025-12-31
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DOI:10.1016/j.nicl.2025.103941delete
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• 抑郁症易感标记物在患者及其家庭成员中存在共享。 • fMRI标记物显示在面部感知期间背侧注意网络活动发生改变。 • 这些变化与乙酰胆碱介导的下行调控作用一致。 • 这些变化在无抑郁症病史的家庭成员中也能观察到。 • 抑感易感性涉及事件神经处理过程的一般性改变。
Keyword:
Major depression disorder
Face perception
Task-related fMRI
Resting-state functional connectivity
Visual attention network
Acetylcholine
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neuroimage: clinical
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