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Design and Mechanical Characterization of Novel Hierarchical Dual-Zone Lattice Structures for Biomimetic Bone Scaffolds
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DOI：10.1016/j.jmbbm.2026.107510.png)
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Abstract
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This study presents the design and mechanical evaluation of a novel bone-mimicking hierarchical lattice structure. A cylindrical specimen (20 mm diameter × 20 mm height) was partitioned into two concentric regions to emulate the heterogeneity of natural bone: a solid inner core (10 mm diameter) and an outer annular region (10-20 mm). Distinct cylindrical lattice architectures were assigned to each region using nTopology software. To introduce hierarchical complexity, rectangular lattice structures were embedded within the cylindrical lattice walls of the inner region, while the outer annulus maintained a conventional cylindrical lattice morphology. Lattice topologies (G, D, L, and S types) and arc counts (2 and 4) were systematically varied based on a Taguchi design of experiments (DOE), enabling controlled investigation of topology combinations and geometric parameters.
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