Designing peptide nanoparticles for efficient brain delivery

Aroa Duro‐Castaño

doi:10.1016/j.addr.2020.10.001

2020-01-01

DOI：10.1016/j.addr.2020.10.001

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摘要

En 中文

The targeted delivery of therapeutic compounds to the brain is arguably the most significant open problem in drug delivery today. Nanoparticles (NPs) based on peptides and designed using the emerging principles of molecular engineering show enormous promise in overcoming many of the barriers to brain delivery faced by NPs made of more traditional materials. However, shortcomings in our understanding of peptide self-assembly and blood-brain barrier (BBB) transport mechanisms pose significant obstacles to progress in this area. In this review, we discuss recent work in engineering peptide nanocarriers for the delivery of therapeutic compounds to the brain: from synthesis, to self-assembly, to in vivo studies, as well as discussing in detail the biological hurdles that a nanoparticle must overcome to reach the brain. (C) 2020 Published by Elsevier B.V.

Keyword:

Peptides

Self-assembly

Drug delivery

Blood-brain barrier

Transcytosis

Glioma

Alzheimer's disease

Parkinson's disease

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期刊

Advanced Drug Delivery Reviews

IF:

17.6

论文数:

4.5K

被引数:

5.1W

机构

University of London

学者数:

1.5K

论文数: 658

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