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Development of a new 18F-labeled PET tracer for potential application to HDAC2 neuroimaging
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DOI：10.1016/j.nucmedbio.2026.109620.png)
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Abstract
En 中文
• HDAC2 inhibitor HYF005 labeled with Fluorine-18 was synthesized and preliminary assessment. • [18F]HYF005 demonstrated appropriate blood-brain barrier (BBB) penetration in rodent models. • [18F]HYF005 holds significant promise as a potential PET imaging probe for the study of the brain's HDAC2 system.
Keywords:
HDAC2
PET imaging
Fluorine-18
blood-brain barrier
radiotracer
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