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Diagnostic and therapeutic evaluation of Blomia tropicalis in patients with allergic rhinitis
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DOI：10.1080/1750743X.2025.2570903.png)
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Abstract
En 中文
To assess the clinical relevance ofB. tropicalisIgE sensitization through nasal challenge test (NCT) and explore the effectiveness of immunotherapy (AIT) with this mite.
A prospective cohort study was conducted in patients with moderate/severe persistent allergic rhinitis. In phase one, atopy tests forB. tropicaliswere evaluated using NCT as reference parameter. In phase two, NCT-positive patients underwent AIT for 1 year, followed by a second NCT.
Eighty patients sensitized toB. tropicaliswere enrolled; 56% had a positive baseline NCT. The SPT and sIgE exhibited a sensitivity over 90%, but a specificity lower than 50% with an overall diagnostic accuracy of 64%. The sIgE to Blo t 5 exhibited a sensitivity of 59.9%, specificity of 80%, and overall diagnostic accuracy 72%. Of those with positive NCT, 39 started AIT. During the second NCT, 82% of these patients tolerated aB. tropicalisextract concentration tenfold higher than baseline.
B. tropicalisis clinically relevant for allergic rhinitis patients, but atopy tests for this disease have a low specificity. AIT withB. tropicalisis a therapeutic tool for allergic rhinitis, mainly when a positive-NCT is demonstrated.
Keywords:
Atopy
Blomia tropicalis
Diagnostic performance
House Dust Mites
Rhinitis
Nasal Challenge Test
Nasal Provocation Test
Immunotherapy
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