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Difference interferometer with new phase-measurement method as integrated-optical refractometer, humidity sensor and biosensor
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DOI：10.1016/S0925-4005(97)80226-2.png)
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摘要
En 中文
The object of the present paper is to report on new versions of the difference interferometer which have been sucessfully used for refractometric measurements and for humidity-and biosensing, i.e., for real-time monitoring of the adsorption of proteins and of affinity-and immunoreactions. The basic principle of the difference interferometers is as follows: the TE0 and TM0 modes in a planar (or rib) waveguide are coherently excited and propagate on a common path and interact with the sample. The polarization-dependent interaction induces a time-dependent phase difference Delta<(Phi)over tilde>(t) between the TE0 and TM0 modes, which is measured as the interferometer's response. We have developed different methods to measure the phase difference a Delta<(Phi)over tilde>(t). The new methods have some advantages and can be expected to be easily extendable to multichannel (multianalyte) sensing. In the reported experiments we use not only SiO2-TiO2 but also Si3N4 films as high-refractive-index waveguides on oxidized silicon wafers as substrates.
Keyword:
integrated-optical interferometric sensor
biosensors
immunosensors
integrated-optical refractometers
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7.7
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3.4W
被引数:
12.6W
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