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Diffusing caveolin-1 scaffolds regulate mechanosignalling

delete2026-06-01
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PRE
AI
V
Victor Breton
C
Céline Gracia
G
Ghassan Hamarneh
I
Ivan R. Nabi
P
Philippe Cuniasse
P
Pierre Sens
G
Grégory Giannone
C
Cédric M. Blouin *
C
Christophe Lamaze *
DOI：10.1038/s41556-026-01966-0delete
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摘要

摘要

En 中文
Caveolae是内陷的质膜纳米域，传统上与膜转运和信号传导相关。这些多功能细胞器也是介导细胞对机械应力响应的必要力感受器。我们研究了caveolae力学在调控各种信号通路中的作用。单分子成像和超分辨率显微镜显示，机械应力迅速触发caveolae解聚和caveolin-1支架的释放，随后在质膜上表现出增强的扩散。这促进了caveolin-1支架结构域与酪氨酸激酶JAK1的直接相互作用，导致其催化活性受到抑制。在eNOS、PTEN和PTP1B中也观察到类似过程。基于caveolae热力学建立的模型进一步验证了由扩散的Cav1支架调控信号传导的作用。这些发现建立了一种力转导范例，其中信号信息通过在信号效应物和caveolin-1支架之间动态且可逆地组装张力控制的复合物，从初始的力感受caveola处远程解码。Mani、Tardif、Rossier等人表明，机械应力触发caveolin-1从caveolae释放，使其在质膜中扩散并与信号效应物相互作用以调控细胞内信号传导。

期刊

Nature Cell Biology 封面图
Nature Cell Biology
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19.1
论文数:
6.2K
被引数:
4.8W

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Institut Curie and PSL Research University
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22
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M
mines paristech
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université paris-saclay, cea and cnrs
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45
论文数: 10
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U
university of bordeaux
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396
论文数: 161
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simon fraser university
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1.7K
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CNRS and Sorbonne University
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13
论文数: 9
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University of British Columbia
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被引数: 8.6W
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引用论文

引用论文

Kinase-regulated quantal assemblies and kiss-and-run recycling of caveolae
errNature
IF0
err2005-07-01
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errLucas Pelkmans; Marino Zerial
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Lessons from cavin-1 deficiency
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IF4.3
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errLiu, Libin
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Structure-Based Reassessment of the Caveolin Signaling Model: Do Caveolae Regulate Signaling through Caveolin-Protein Interactions?
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IF8.7
err2012-07-01
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errCollins, Brett M.; Davis, Melissa J.; Hancock, John F.; Parton, Robert G.
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Interaction of a receptor tyrosine kinase, EGF-R, with caveolins - Caveolin binding negatively regulates tyrosine and serine/threonine kinase activities
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err1997-11-01
err617
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errCouet, J; Sargiacomo, M; Lisanti, MP
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Identification of peptide and protein ligands for the caveolin-scaffolding domain - Implications for the interaction of caveolin with caveolae-associated proteins
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
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errCouet, J; Li, SW; Okamoto, T; Ikezu, T; Lisanti, MP
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EHD2 is a mechanotransducer connecting caveolae dynamics with gene transcription
errJOURNAL OF CELL BIOLOGY
IF6.4
err2018-10-22
err59
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errTorrino, Stephanie; Shen, Wei-Wei; Blouin, Cedric M.; Mani, Satish Kailasam; de Lesegno, Christine Viaris; Bost, Pierre; Grassart, Alexandre; Koster, Darius; Valades-Cruz, Cesar Augusto; Chambon, Valerie; Johannes, Ludger; Pierobon, Paolo; Soumelis, Vassili; Coirault, Catherine; Vassilopoulos, Stephane; Lamaze, Christophe
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Evaluating Caveolin Interactions: Do Proteins Interact with the Caveolin Scaffolding Domain through a Widespread Aromatic Residue-Rich Motif?
errPLoS ONE
IF0
err2012-09-17
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errDominic P. Byrne; Caroline Dart; Daniel J. Rigden
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Caveolin, a protein component of caveolae membrane coats
errCell
IF0
err1992-02-01
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errKaren G. Rothberg; John E. Heuser; William C. Donzell; Yun-Shu Ying; John R. Glenney; Richard G.W. Anderson
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Effect of stretch and contraction on caveolae of smooth muscle cells
errCell and Tissue Research
IF0
err1978-01-01
err0
PREAI
errGiorgio Gabella; David Blundell
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Novel imaging methods and force probes for molecular mechanobiology of cytoskeleton and adhesion
errTRENDS IN CELL BIOLOGY
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err2023-03-01
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errVicente, Filipe Nunes; Chen, Tianchi; Rossier, Olivier; Giannone, Gregory
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