.png){kind=icon}
返回
Diffusion-prepared 3D gradient spin-echo sequence for improved oscillating gradient diffusion MRI
.png){kind=icon}
PRE
AI
DOI：10.1002/mrm.28401.png)
.png){kind=icon}
原文求助.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Purpose Oscillating gradient (OG) enables the access of short diffusion times for time-dependent diffusion MRI (dMRI); however, it poses several technical challenges for clinical use. This study proposes a 3D oscillating gradient-prepared gradient spin-echo (OGprep-GRASE) sequence to improve SNR and shorten acquisition time for OG dMRI on clinical scanners. Methods The 3D OGprep-GRASE sequence consisted of global saturation, diffusion encoding, fat saturation, and GRASE readout modules. Multiplexed sensitivity-encoding reconstruction was used to correct the phase errors between multiple shots. We compared the scan time and SNR of the proposed sequence and the conventional 2D-EPI sequence for OG dMRI at 30-90-mm slice coverage. We also examined the time-dependent diffusivity changes with OG dMRI acquired at frequencies of 50 Hz and 25 Hz and pulsed-gradient dMRI at diffusion times of 30 ms and 60 ms. Results The OGprep-GRASE sequence reduced the scan time by a factor of 1.38, and increased the SNR by 1.74-2.27 times compared with 2D EPI for relatively thick slice coverage (60-90 mm). The SNR gain led to improved diffusion-tensor reconstruction in the multishot protocols. Image distortion in 2D-EPI images was also reduced in GRASE images. Diffusivity measurements from the pulsed-gradient dMRI and OG dMRI showed clear diffusion-time dependency in the white matter and gray matter of the human brain, using both the GRASE and EPI sequences. Conclusion The 3D OGprep-GRASE sequence improved scan time and SNR and reduced image distortion compared with the 2D multislice acquisition for OG dMRI on a 3T clinical system, which may facilitate the clinical translation of time-dependent dMRI.
Keyword:
3D-GRASE
diffusion-time dependency
oscillating gradient
signal-to-noise ratio | scan time
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
3
论文数:
1.2W
被引数:
3.1W
机构
引用论文
分享收藏Fast 3D Chemical Exchange Saturation Transfer (CEST) Imaging of the Human Brain人脑的快速3D化学交换饱和转移 (CEST) 成像
OAAI
OAAI分享收藏GRASE (GRADIENT-ECHO AND SPIN-ECHO) MR IMAGING - A NEW FAST CLINICAL IMAGING TECHNIQUE.png)
RADIOLOGY
RADIOLOGYIF15.2
PREAI
分享收藏
查看更多内容