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Digitally generated Trail Making Test data: Analysis using hidden Markov modeling

delete2022-03-08
delete7
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OA
AI
M
Mengtian Du *
S
Stacy L. Andersen
S
Stephanie Cosentino
R
Robert M. Boudreau
T
Thomas T. Perls
P
Paola Sebastiani
DOI:10.1002/dad2.12292delete
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摘要

摘要

En 中文
The Trail Making Test (TMT) is a neuropsychological test used to assess cognitive dysfunction. The TMT consists of two parts: TMT-A requires connecting numbers 1 to 25 sequentially; TMT-B requires connecting numbers 1 to 12 and letters A to L sequentially, alternating between numbers and letters. We propose using a digitally recorded version of TMT to capture cognitive or physical functions underlying test performance. We analyzed digital versions of TMT-A and -B to derive time metrics and used Bayesian hidden Markov models to extract additional metrics. We correlated these derived metrics with cognitive and physical function scores using regression. On both TMT-A and -B, digital metrics associated with graphomotor processing test scores and gait speed. Digital metrics on TMT-B were additionally associated with episodic memory test scores and grip strength. These metrics provide additional information of cognitive state and can differentiate cognitive and physical factors affecting test performance.
Keyword:
aging
Bayesian hidden Markov models
cognitive function
digital biomarker
Trail Making Test

期刊

A
Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
IF:
4.4
论文数:
815
被引数:
3.0K

机构

C
Columbia University
学者数:
7.1W
论文数: 6.4W
被引数: 263
B
boston university
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3.8W
论文数: 3.2W
被引数: 67
U
University of Pittsburgh
学者数:
4.5W
论文数: 3.6W
被引数: 7.1W
P
pennsylvania commonwealth system of higher education (pcshe)
学者数:
12.9W
论文数: 11.7W
被引数: 177
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