Dimdazenil: First Approval

Yahiya Y. Syed

doi:10.1007/s40265-024-02020-9

2024-03-28

PRE

Yahiya Y. Syed *

DOI：10.1007/s40265-024-02020-9

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Dimdazenil (Junoenil (R)) is a small-molecule, oral, partial positive allosteric modulator of the gamma-aminobutyric acid (GABA)A receptor that is being developed by Zhejiang Jingxin Pharmaceutical in collaboration with Evotec for the treatment of insomnia. Dimdazenil is designed to overcome issues associated with full GABAA receptor agonists, such as tolerance, withdrawal symptoms and associated adverse effects. On 29 November 2023, dimdazenil oral capsules received approval in China for the short-term treatment of insomnia. This article summarizes the milestones in the development of dimdazenil leading to this first approval for insomnia.

Keyword:

TRAFFIC NOISE MODEL

DOUBLE-BLIND

CROSS-OVER

EVT-201

SLEEP

PERFORMANCE

MODULATOR

GABA(A)

期刊

Drugs

IF:

14.4

论文数:

8.4K

被引数:

2.3W

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